Scientists struggle to understand why some gut bacteria are sensitive to antibiotics while a fraction of them survive treatment. New research in mice reveals that gut microbial metabolism alongside diet play a key role in modifying the extent of gut microbiome disruption in response to antibiotics.

Crohn’s Disease (CD) is one of the sets of inflammatory bowel disease (IBD) that consists of chronic inflammation of the terminal ileum, that can extend throughout the gastrointestinal tract. Researchers have focused more on the role the gut microbiota plays in CD over the years to better understand disease progression. Increased endotoxemia, inflammation, fungal loads and changes in the gut microbiota composition, as well as altered mucins production have been observed in CD patients compared to healthy populations.

The purpose of the article is to uncover how dietary components and long-term dietary patterns interact with and influence gut microbiota composition and function and intestinal inflammation.

As the saying goes, an apple a day keeps the doctor away, but figuring out exactly how long-term dietary patterns affect the gut microbiome’s role in regulating inflammation has not been quite as clear for researchers.

Diet has been shown to play a role in both IBD and IBS symptoms and possibly disease progression