Inter-individual gut microbiome variation remains one of the major caveats in this field of research. Scientists from different countries update the role of socio-demographic and environmental factors in inter-individual gut microbiome variation in healthy French adults.

Although the gut microbiome remains relatively stable throughout adulthood, various environmental factors such as disease, and diet have been reported to affect the gut microbiota composition. Although host genotype may influence relative abundance of microbial taxa, only few associations between host genetics and gut microbiota diversity have been found. Thus, inter-individual gut microbiome variation remains largely unexplained.