Increasing evidence suggests that imbalanced gut microbiota may play a role in insulin resistance in Type 2 Diabetes patients and exercise has shown to have positive effects on the gut microbiome and metabolism.

Several studies over the past decade have associated the gut microbiome and metabolic disorders such as obesity and type 2 diabetes (T2D), yet the exact mechanisms are not fully understood.

Recent studies show that the gut microbiota may affect our body’s response to insulin, a hormone that helps glucose enter the body’s cells so it can be used as energy.

The microbes that inhabit our intestines are responsible for several functions such as synthesizing vitamins as well as modulating our immune system, metabolism and blood sugar levels. Recent studies show that the gut microbiota may affect our body’s response to insulin, a hormone that helps glucose enter into the body’s cells so that it can be used as energy. For this reason, many researchers are interested in targeting the gut microbiota to improve obesity-associated blood glucose impairment since many obese and type 2 diabetes patients suffer from decreased insulin sensitivity and increased blood sugar, also known as insulin resistance. For example, imbalances of the gut microbiota have been associated with insulin resistance in patients with obesity and other metabolic diseases such as type 2 diabetes.

Consuming probiotics is beneficial for treating metabolic diseases such as obesity, diabetes and non-alcoholic fatty liver disease, which are a global health problem.

Obesity, diabetes and non-alcoholic fatty liver disease (NAFLD, which is excessive fat accumulation in the liver) are a growing global health problem. Researchers believe that lifestyle, especially a poor diet, contributes to the rapid progression of these diseases. Studies show that patients with metabolic diseases such as type 2 diabetes, obesity and NAFLD also have dysbiosis, which is an imbalanced gut microbiota. Dysbiosis is characterized by decreased levels of beneficial bacteria.  Metformin, a common drug given to type 2 diabetes patients to regulate blood sugar levels, modulates the gut microbiota in a way that leads to improved blood glucose levels.

Restrictive diets in terms of calories and nutrients are widespread among people. Although this type of diets could help with weight loss in the short term, their long-term effects on the gut microbiome and overall health remain unknown.

How diet affects a person’s weight appears to be much more complex than previously thought due to the potential role the gut microbiome plays in nutrient absorption, energy production, inflammation and metabolism.

It’s now well known that diet greatly influences the gut microbiome, and more recently research has shed light on how the gut microbiome is altered in obese vs normal weight individuals.